Curvature Entropy Trapping of Long DNA under Hydrodynamic Flows in Microfluidic Devices

Masanori Ueda, Tetsuya Hayama, Yuzuru Takamura, Yasuhiro Horiike
Tomonari Dotera and Yoshinobu Baba

Jpn. J. Appl. Phys. 43 (2004), pp.1649-1650

We investigated the curvature effect on the dynamics of long DNA using microfluidic devices. Long DNA has larger configurational entropy in a curved channel than in a straight channel. Under weak hydrodynamic flows, long DNA exhibited a curvature entropy trapping effect. The effect disappeared as the hydrodynamic flow was increased.